Saracens revert to their strongest possible side as they aim to beat reigning champions Harlequins in the first Premiership semi-final.
England captain Owen Farrell leads a Sarries side that sees Maro Itoje make his 150th appearance for the club.
Quins make two changes from the side that lost a 13-try thriller at Exeter.
Huw Jones returns at full-back, Tyrone Green moves to the wing in place of the injured Louis Lynagh while Cadan Murley replaces Aaron Morris out wide.
The winners will face either Leicester or Northampton in the final at Twickenham a week on Saturday, 18 June.
Leicester v Northampton semi-final preview
It is Saracens' first play-off game since they beat Exeter to win the 2019 Premiership final.
The club were relegated at the end of the following season after breaching the Premiership's salary cap rules and won an abridged Championship last season.
This term Mark McCall's side won 17 and lost six of their regular-season matches as they finished second in the Premiership, seven points behind Leicester.
After making 15 changes for a 54-7 loss at Gloucester last week., they recall a host of international stars including England quartet Mako and Billy Vunipola, Maro Itoje and Jamie George, and Springbok World Cup-winning prop Vincent Koch.
Welsh scrum-half Aled Davies joins Farrell at half-back with Alex Goode, Sean Maitland, Elliot Daly and Nick Tompkins also returning to the backline alongside Max Malins.
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'There are more intimidating grounds than Saracens'
"It's something we've been thinking about or aspiring to be in this position for the last 18 months or so," George told BBC Radio London.
"To be back in it, it's where we want to be, it's where we feel most comfortable, it's where we feel most confident and generally it brings the best out of us.
"Things are looking pretty similar to years before. The intensity of training's increased, as ever, but at the same time there's a really good feeling in the camp.
"We talk about building towards something. We're here now, it's time to show up and it's time to put everything together."
Champions Quins 'will stand their ground'
A year ago Quins won a dramatic semi-final 43-36 in extra time at table-topping Bristol.
They carried that momentum into the final a week later to beat much-fancied Exeter at Twickenham as Lynagh scored two late tries in a see-saw battle.
Whereas Saracens opted to rest their frontline players last week, Quins deployed most of theirs at Sandy Park, having played just once since the end of April.